CD19 CAR lentiviral vector (BaEV pseudotype)

CD19 CAR lentiviral vector (BaEV pseudotype) is a gene therapy tool designed to engineer cells to express a chimeric antigen receptor (CAR) targeting the CD19 antigen. This specific vector is pseudotyped with the Baboon envelope (BaEV) glycoprotein, which utilizes the ASCT1 and ASCT2 neutral amino acid transporters as entry receptors. This pseudotyping strategy is intended to overcome the limitations of standard VSV-G pseudotyped vectors, particularly in the transduction of quiescent or hard-to-transduce cells like hematopoietic stem cells (HSCs) and resting T cells. Developed by researchers associated with Miltenyi Biotec, the vector is optimized for use in automated, closed-system manufacturing platforms like the CliniMACS Prodigy to enhance the scalability and standardization of CAR-based therapies for B-cell malignancies.

Other names

Baboon envelope pseudotyped LVBaEV-LV CD19 CARBaEV pseudotyped lentiviral vector