CD19 CAR lentiviral vector (VSV-G pseudotype)

CD19 CAR lentiviral vector (VSV-G pseudotype) is a gene therapy tool used to engineer cells, typically T cells or hematopoietic stem cells (HSCs), to express a chimeric antigen receptor (CAR) targeting the CD19 protein. The vector is based on a lentiviral backbone, which allows for stable integration of the CAR transgene into the host cell genome, ensuring long-term expression. It is pseudotyped with the Vesicular Stomatitis Virus G (VSV-G) glycoprotein, which provides broad tropism by binding to the low-density lipoprotein receptor (LDLR) ubiquitous on many cell types, and enhances the stability of the viral particles for manufacturing. This specific vector configuration is frequently used in the development of CAR-T cell therapies for B-cell malignancies and is often employed in studies optimizing automated cell processing platforms, such as the Miltenyi Biotec CliniMACS Prodigy, to improve transduction efficiency and scalability.

Other names

CD19 CAR LV (VSV-G)VSV-G pseudotyped CD19 CAR lentiviral vector