Drug intelligence / Profile preview

CD19-CD22 CAR-T

Development stage
Unknown
Lead developer
Stanford Medicine
Modality
CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

**CD19-CD22 CAR-T** is a nonspecific, target-defined category of engineered T-cell therapies rather than one uniquely identifiable drug product. These autologous or potentially allogeneic CAR-T-cell products are designed to recognize **B-lymphocyte antigen CD19** and **B-lymphocyte antigen CD22**, two surface antigens commonly expressed by malignant B cells. Dual targeting is intended to improve antitumor activity and reduce relapse caused by loss or downregulation of either single antigen. Multiple distinct CD19-CD22 CAR-T programs have been evaluated clinically for relapsed or refractory B-cell acute lymphoblastic leukemia and B-cell lymphomas, including diffuse large B-cell lymphoma and central nervous system lymphoma.

Other names
CD19 and CD22 CAR-T cellsCD-19 and CD22 CAR-T cellsCD 19 and CD22 CAR-T cellsCD19-CD22 CAR+ T cellsCD19-CD22 CAR-T cellsCD-19-CD22 CAR-T cellsCD 19-CD22 CAR-T cellsCD19/CD22 CAR-T cellsHuman CD19-CD22 Targeted T Cells
02

Targets

CD19 (B lymphocyte antigen CD19)CD22 (Cluster of Differentiation 22)

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