CD19xCD3 diabody TCE

CD19xCD3 diabody TCE is a bispecific T-cell engager (TCE) designed in a compact diabody format that simultaneously targets CD19 on B cells and CD3 on T cells. Developed as a potential off-the-shelf alternative to CD19 CAR T-cell therapies for deep B-cell depletion in autoimmune diseases, this molecule's compact architecture is optimized to maximize B-cell cytotoxicity. Preclinical studies have demonstrated that the compact diabody format achieves robust, dose-dependent B-cell depletion in vitro and near-complete depletion in vivo across blood, spleen, and bone marrow, outperforming larger IgG-like formats despite having lower B-cell binding intensity.

Other names

CD19xCD3 diabodyCD-19xCD3 diabodyCD 19xCD3 diabodyCD19xCD3 diabody T-cell engagerCD-19xCD3 diabody T-cell engagerCD 19xCD3 diabody T-cell engager