CD206 antagonist peptide

CD206 antagonist peptides are a class of synthetic or naturally derived peptides designed to target and modulate the activity of the macrophage mannose receptor (CD206/MRC1), which is highly expressed on alternatively activated (M2-polarized) macrophages. These peptides, such as RP-182, RP-832c, and RP606-30, typically bind to the carbohydrate recognition domains (such as CRD5) of CD206, inducing conformational changes that can reprogram immunosuppressive or pro-fibrotic M2 macrophages toward a pro-inflammatory or pro-resolving M1-like phenotype. CD206 antagonist peptides are being investigated for their therapeutic potential in oncology (to disrupt the immunosuppressive tumor microenvironment), fibrotic diseases (such as systemic sclerosis and pulmonary fibrosis), and inflammatory conditions like rheumatoid arthritis.

Other names

CD206 antagonist peptidesCD-206 antagonist peptidesCD 206 antagonist peptidesCD206 modulatorsCD-206 modulatorsCD 206 modulatorsCD206-targeting peptidesCD-206-targeting peptidesCD 206-targeting peptidesmannose receptor antagonist peptides