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CD35-EVs
- Development stage
- Preclinical
- Lead developer
- Southeast University
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01
Overview
CD35-EVs (CD35-positive extracellular vesicles) are podocyte-derived extracellular vesicles expressing complement receptor type 1 (CD35/CR1). Developed by Southeast University and Zhongda Hospital, these vesicles are being investigated for the treatment of sepsis-associated acute kidney injury (SA-AKI) and multi-organ injury. CD35-EVs are internalized by monocytes, where they directly bind to intracellular complement fragment C3b, thereby inhibiting alternative pathway-dependent complosome activation, reversing glycolytic reprogramming, and suppressing monocyte chemotaxis and infiltration into injured tissues.
- Other names
- CD35-positive EVsCD-35-positive EVsCD 35-positive EVsCD35-positive extracellular vesiclesCD-35-positive extracellular vesiclesCD 35-positive extracellular vesiclespodocyte-derived CD35-positive extracellular vesicles
02
Targets
C3b (Complement Component 3b)C4B (Complement component 4B)
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