CD5-2

CD5-2 is a 20-amino acid peptide derived from the second scavenger receptor cysteine-rich (SRCR) domain of the human CD5 surface glycoprotein. CD5 is a well-known lymphocyte receptor that modulates T-cell and B-cell activation and survival. The CD5-2 peptide was specifically designed to mimic the binding interface of the CD5 ectodomain, allowing it to competitively inhibit the interaction between CD5 and its ligands, such as CD5-like protein (CD5L, also known as AIM or Sp-alpha). Preclinical research has demonstrated that CD5-2 possesses significant anti-inflammatory and immunomodulatory properties. It has been investigated primarily as a therapeutic candidate for the treatment of severe inflammatory conditions, including sepsis and systemic inflammatory response syndrome (SIRS), where it appears to reduce the production of pro-inflammatory cytokines and improve survival rates in animal models. The peptide is also used as a research tool to study the structural biology and signaling pathways associated with the CD5 receptor.

Other names

CD5-derived peptide 2CD-5-derived peptide 2CD 5-derived peptide 2CD5 domain 2 peptideCD-5 domain 2 peptideCD 5 domain 2 peptide