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CD7 CAR-T + autologous hematopoietic stem cell transplantation
- Development stage
- Unknown
- Lead developer
- Zhengzhou University
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Stem Cell Therapies → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
CD7 CAR-T + autologous hematopoietic stem cell transplantation is an investigational combination therapy being evaluated by Zhengzhou University for the treatment of relapsed or refractory CD7-positive T-cell lymphomas. The treatment protocol integrates high-dose chemotherapy (typically the BEAM regimen) followed by autologous hematopoietic stem cell transplantation (ASCT) to rescue the bone marrow, and the subsequent infusion of chimeric antigen receptor (CAR) T cells engineered to target the CD7 antigen. This sequential approach is intended to maximize tumor debulking through intensive conditioning while providing a targeted cellular immunotherapy to eradicate residual lymphoma cells and prevent relapse. The therapy is currently being studied in a Phase I/II clinical trial to determine the maximum tolerated dose and preliminary efficacy.
- Other names
- CD7 CAR-T + ASCTCD7 CAR-T combined with autologous hematopoietic stem cell transplantationCD-7 CAR-T combined with autologous hematopoietic stem cell transplantationCD 7 CAR-T combined with autologous hematopoietic stem cell transplantationCD7-targeted chimeric antigen receptor T cells combined with autologous stem cell transplantationCD-7-targeted chimeric antigen receptor T cells combined with autologous stem cell transplantationCD 7-targeted chimeric antigen receptor T cells combined with autologous stem cell transplantation
02
Targets
CD7 (CD7 antigen)
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