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CD7-targeted CAR-T cells (Donghua Zhang)
- Development stage
- Unknown
- Lead developer
- Gracell Biotechnologies
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
CD7-targeted CAR-T cells are an investigational chimeric antigen receptor (CAR) T-cell therapy designed to target the CD7 protein, which is highly expressed in various T-cell malignancies and some myeloid leukemias. Developed as part of an investigator-initiated trial (IIT) led by Donghua Zhang, these T cells are genetically modified to express a CAR that recognizes and binds to CD7-positive tumor cells, triggering T-cell activation and subsequent tumor cell destruction. The therapy is primarily being evaluated for the treatment of relapsed or refractory (r/r) CD7-positive hematological malignancies, including acute T-lymphoblastic leukemia (T-ALL), T-lymphoblastic lymphoma (T-LBL), and acute myeloid leukemia (AML).
- Other names
- CD7-targeted chimeric antigen receptor gene-modified T cellsCD-7-targeted chimeric antigen receptor gene-modified T cellsCD 7-targeted chimeric antigen receptor gene-modified T cellsCD7-Targeted Chimeric Antigen Receptor (CAR) Gene-Modified T Cells for the Treatment of CD7-Positive Hematological MalignanciesCD7 CAR-T cellsCD-7 CAR-T cellsCD 7 CAR-T cells
02
Targets
CD7 (CD7 antigen)
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