Drug intelligence / Profile preview

CDCA1 peptide + KIF20A peptide + LY6K peptide

Development stage
Unknown
Modality
Peptides, Vaccines & Immunotherapeutics
Administration
Subcutaneous, Intradermal
01

Overview

This is a combination cancer vaccine composed of three synthetic peptides derived from the tumor-associated antigens CDCA1 (Cell Division Cycle Associated 1), KIF20A (Kinesin Family Member 20A), and LY6K (Lymphocyte Antigen 6 Complex Locus K). Each component is designed to stimulate an immune response against cancer cells expressing these antigens. The vaccine aims to induce cytotoxic T lymphocyte (CTL) and helper T cell responses, thereby promoting targeted destruction of tumor cells. All three antigens are overexpressed in various cancers, including prostate, breast, head-and-neck, and esophageal cancers. This multipeptide approach seeks to enhance immunogenicity and reduce the risk of immune escape by targeting multiple essential tumor proteins simultaneously[2][5][6][7].

Other names
CDCA1 + KIF20A + LY6K
02

Targets

TCR-KIF20A-pMHC (T-cell receptor recognizing Kinesin family member 20A-derived peptide–MHC complexes)TCR-CDCA1-pMHC (T-cell receptor recognizing Cell division cycle-associated protein 1-derived peptide–MHC complexes)TCR (T cell antigen receptor complex)

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