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CDR111
- Development stage
- Unknown
- Lead developer
- CDR-Life
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Trispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
01
Overview
CDR111 is a trispecific T cell engager antibody developed by CDR-Life for the treatment of autoimmune diseases. It is designed to achieve immune reset through broad B cell depletion by simultaneously targeting CD19, BCMA (B-cell maturation antigen), and CD3. This approach aims to deplete pathogenic B cells while engaging T cells, offering a novel therapeutic strategy for multiple autoimmune conditions. The molecule represents an expansion of CDR-Life’s portfolio beyond oncology into immunology and leverages their proprietary M-gager platform for modular antibody engineering[2][5][6].
02
Targets
CD19 (B lymphocyte antigen CD19)CD3 (T-cell surface glycoprotein CD3)BCMA (B-cell maturation antigen)
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