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CEA CAR-T
- Development stage
- Preclinical
- Lead developer
- Guangzhou FineImmune Biotechnology
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
CEA CAR-T is an autologous chimeric antigen receptor (CAR) T-cell therapy being developed by Guangzhou FineImmune Biotechnology for the treatment of colorectal cancer and other CEA-positive solid tumors. Utilizing the company's proprietary "SUPER CAR-T" platform, the therapy involves the genetic modification of a patient's T cells to express a CAR that specifically recognizes Carcinoembryonic Antigen (CEA), a cell-surface glycoprotein that is overexpressed in approximately 90% of colorectal cancers. Once re-infused into the patient, these engineered T cells are designed to selectively bind to and destroy tumor cells expressing the CEA antigen, potentially overcoming the immunosuppressive environment of solid tumors. The asset is part of a broader pipeline of cell therapies targeting solid tumor antigens.
- Other names
- CEA-targeted CAR-Tanti-CEA CAR-T
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