CEACAM5 clickable Fab

CEACAM5 clickable Fab is a specialized monoclonal antibody fragment (Fab) engineered to target Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5), a well-validated tumor-associated antigen overexpressed in various epithelial malignancies, including colorectal, pancreatic, and lung cancers. The 'clickable' feature refers to the site-specific incorporation of a bioorthogonal chemical handle, such as trans-cyclooctene (TCO) or an azide group, which enables rapid and selective 'click chemistry' reactions in vivo. This construct is a cornerstone of pre-targeting strategies, where the Fab fragment is first administered to accumulate at the tumor site and clear from the circulation, followed by the administration of a small-molecule imaging or therapeutic agent (e.g., a tetrazine-labeled radioligand). This approach, pioneered by companies like Tagworks Pharmaceuticals, aims to maximize tumor-to-background ratios, thereby enhancing the sensitivity of Immuno-PET imaging and the efficacy of radioimmunotherapy while minimizing systemic toxicity.

Other names

TCO-modified anti-CEACAM5 Fabclickable anti-CEA FabTCO-anti-CEA Fab