ceapinA7

CeapinA7 is a synthetic small molecule that acts as a selective inhibitor of activating transcription factor 6 alpha (ATF6α), a key branch of the unfolded protein response (UPR) pathway. It displays high selectivity for ATF6α over ATF6β and does not inhibit other UPR branches or SREBP signaling. The compound functions by trapping ATF6α in the endoplasmic reticulum, preventing its cleavage and subsequent activation during ER stress, thereby sensitizing cells to ER stress and promoting apoptosis under stress conditions. CeapinA7 is widely used as a research tool for dissecting UPR mechanisms and investigating ATF6α-dependent signaling in cellular and disease models, including cancer, but it is not approved for clinical use. Its use in preclinical models demonstrates enhanced chemosensitivity in certain cancers and the ability to modulate stress responses[1][3][4][6][9][10].

Other names

Ceapin-A7Ceapin-A-7Ceapin-A 7