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Cediranib + Fulvestrant
- Development stage
- Phase 2
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral, Intramuscular
01
Overview
The combination of cediranib and fulvestrant is a therapeutic approach that has been studied for hormone-sensitive metastatic breast cancer. This combination pairs cediranib, a highly potent vascular endothelial growth factor (VEGF) signaling inhibitor that targets all three VEGF receptors, with fulvestrant (brand name Faslodex), an estrogen receptor antagonist with no known agonist effects that competitively binds, blocks, and degrades the estrogen receptor. This combination was investigated to potentially overcome resistance mechanisms in hormone receptor-positive breast cancer. Fulvestrant itself is approved for hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy.
- Other names
- cediranibfulvestrant
02
Targets
ESR1 (ERα)ESR2 (ERβ)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)
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