Drug intelligence / Profile preview

cefaclor

Development stage
Approved
Lead developer
Eli Lilly
Modality
Small Molecules
Administration
Oral
01

Overview

Cefaclor is a second-generation cephalosporin antibiotic used to treat a variety of bacterial infections including pneumonia and other lower respiratory tract infections, skin infections, ear infections (otitis media), throat and tonsil infections (pharyngitis/tonsillitis), and urinary tract infections[1][2][3][4][5]. It works by binding to specific penicillin-binding proteins (PBPs) in the bacterial cell wall, inhibiting the final stage of cell wall synthesis. This leads to cell lysis mediated by autolytic enzymes[3][6]. Cefaclor is effective against many Gram-positive bacteria such as Staphylococci and Streptococcus species as well as certain Gram-negative organisms like Escherichia coli and Haemophilus influenzae[3][6]. It is administered orally. Developers: Eli Lilly

Brand names
CeclorCeclor PulvulesCeclor CDRaniclor
Other names
cefaclor
02

Targets

PBP1A (Penicillin-binding protein 1A)

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