cefamandole

Cefamandole is a second-generation, broad-spectrum cephalosporin antibiotic of the beta-lactam class. It is primarily administered parenterally as its prodrug form, cefamandole nafate. Cefamandole exerts bactericidal activity by binding to penicillin-binding proteins (PBPs) in bacterial cell walls, thereby inhibiting the final stage of peptidoglycan synthesis and leading to cell lysis. It is effective against a wide range of gram-positive and gram-negative bacteria, including strains resistant to other cephalosporins such as Enterobacter species and indole-positive Proteus species. Clinically, it has been used for serious infections like lower respiratory tract infections (including pneumonia), urinary tract infections, peritonitis, septicemia, skin and soft tissue infections, and bone/joint infections caused by susceptible organisms[1][3][5][7]. The drug is no longer marketed in the United States but may still be available in some countries. Cefamandole contains an N-methylthiotetrazole (NMTT) side chain that can cause hypoprothrombinemia (likely via inhibition of vitamin K epoxide reductase) and disulfiram-like reactions with ethanol due to inhibition of aldehyde dehydrogenase; vitamin K supplementation may be recommended during therapy[7].

Brand names

Mandol

Other names

cefamandole nafate