cefazolin + metronidazole + lidocaine + epinephrine

**Cefazolin + metronidazole + lidocaine + epinephrine** is a multi-drug formulation administered as a tumescent solution, primarily for the prevention of surgical site infections (SSIs) during procedures at high infection risk, such as open colorectal surgery. The antibiotics, **cefazolin** (a first-generation cephalosporin) and **metronidazole** (a nitroimidazole antibiotic), provide broad-spectrum antimicrobial prophylaxis against aerobic and anaerobic bacteria[1][3]. **Lidocaine**, an amide local anesthetic, prevents perioperative pain through sodium channel blockade, while **epinephrine** serves as a local vasoconstrictor to prolong anesthetic action and reduce systemic absorption of lidocaine, improving local drug retention[1][7]. This combination is delivered via **tumescent anesthesia antibiotic delivery (TAAD)**, in which all four components are diluted in saline (with sodium bicarbonate), and infiltrated subcutaneously. This technique achieves high interstitial concentrations of antibiotics, long-lasting anesthesia, and significant local hemostasis[1][3].

Other names

cefazolin + metronidazole + lidocaine + epinephrine