cefepime + ceftazidime

Cefepime + ceftazidime is a combination of two broad-spectrum, parenteral, beta-lactam antibiotics from the cephalosporin class. Cefepime is a fourth-generation cephalosporin with enhanced activity against both Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. Ceftazidime is a third-generation cephalosporin notable for its strong antipseudomonal activity and effectiveness against other resistant Gram-negative organisms. Both drugs act by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. This combination may be considered in clinical scenarios where broad-spectrum coverage for severe or resistant infections is required, although it is not an established fixed-dose commercial product or guideline-recommended regimen; rather, each drug may be used individually or sequentially depending on susceptibility patterns[3][4][5][9].

Brand names

Maxipime (cefepime)Fortaz (ceftazidime)Tazicef (ceftazidime)

Other names

cefepimacefepimumCAZceftazidimceftazidimaceftazidimum