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Penicillin-binding protein 1A
- Molecular classification
- Enzyme, Penicillin-binding protein, Transpeptidase, Transglycosylase
01
Overview
Penicillin-binding protein 1A (PBP1A) is a bacterial enzyme essential for peptidoglycan synthesis and cell wall maintenance. It functions as both a transglycosylase, polymerizing glycan chains, and a transpeptidase, cross-linking peptide subunits. PBP1A is a primary target for β-lactam antibiotics, but mutations can lead to antibiotic resistance. It is crucial for cell division and bacterial viability.
- Other names
- PBP1APBP 1Apbp2xpbp2b
02
Mechanism of action
β-lactam antibiotics inhibit PBP1A's transpeptidase activity by covalently binding to the active site, preventing the cross-linking of peptide subunits in peptidoglycan.
03
Biological functions
Peptidoglycan biosynthesisCell wall synthesisCell divisionSeptum formation
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Antibiotic resistance developmentMutations can alter drug binding affinity
06
Interacting drugs
Penicillins
2 more in the full profile.
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