cefepime + avibactam

Cefepime + avibactam is a combination antibiotic therapy under investigation for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. Cefepime is a fourth-generation cephalosporin antibiotic that exerts its bactericidal effect by binding to penicillin-binding proteins (PBPs), thereby inhibiting bacterial cell wall synthesis and leading to cell lysis and death. Avibactam is a non-beta-lactam beta-lactamase inhibitor that protects cefepime from degradation by inhibiting certain beta-lactamases, including class A, C, and some D enzymes. This combination aims to extend the spectrum of activity of cefepime against resistant organisms, particularly those producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases.

Other names

YK 1169YK1169YK-1169