Drug intelligence / Profile preview

cefiderocol

Development stage
Approved
Lead developer
Shionogi
Modality
Small Molecules
Administration
Intravenous
01

Overview

Cefiderocol is a novel siderophore cephalosporin antibiotic with a unique mechanism of action that allows it to penetrate the outer membrane of Gram-negative bacteria, including multi-drug resistant strains. It is used to treat complicated urinary tract infections and hospital-acquired bacterial pneumonia, including ventilator-associated bacterial pneumonia, caused by susceptible Gram-negative bacteria. Developed by Shionogi & Co., Ltd., it was approved by the FDA in November 2019 and by the EU in April 2020.

Brand names
FetrojaFetcroja
Other names
头孢地尔
02

Targets

PBP1A (Penicillin-binding protein 1A)PBP2 (Penicillin-binding protein 2)PBP3 (Peptidoglycan D,D-transpeptidase FtsI)

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