cefpodoxime + ofloxacin

Cefpodoxime + ofloxacin is a fixed-dose combination antibiotic consisting of cefpodoxime proxetil, a third-generation cephalosporin, and ofloxacin, a second-generation fluoroquinolone. Cefpodoxime works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), while ofloxacin inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV. This combination is typically used for the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, and typhoid fever, particularly where dual coverage or synergistic effects against Gram-positive and Gram-negative pathogens are desired. It is developed and marketed by companies like Cosmas Pharmaceuticals in oral formulations such as tablets and dry syrups.

Brand names

BITUPOD O

Other names

cefpodoxime proxetil + ofloxacin