cefroxadine

Cefroxadine is a semisynthetic, orally available first-generation cephalosporin antibiotic belonging to the β-lactam class. It is structurally related to cefalexin and shares a similar spectrum of activity against both Gram-positive and Gram-negative bacteria. The drug exerts its bactericidal effect by binding to and inhibiting penicillin-binding proteins (PBPs), which are essential for bacterial cell wall synthesis. This inhibition disrupts the cross-linking of peptidoglycan chains, leading to weakening of the cell wall, osmotic instability, and ultimately bacterial lysis. Cefroxadine was primarily used in Italy (and reportedly Japan) for treating various bacterial infections but has since been withdrawn from some markets[1][3][4][5][7].

Brand names

OrasporCefthan-DS

Other names

cefroxadino