ceftazidime

Ceftazidime is a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram-negative and some Gram-positive bacteria. It is particularly effective against Pseudomonas aeruginosa and other resistant Gram-negative organisms. The drug acts by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), thereby disrupting peptidoglycan cross-linking essential for cell wall integrity and leading to bacterial lysis. Ceftazidime is administered primarily via intravenous or intramuscular injection and is used in the treatment of serious infections such as pneumonia (including hospital-acquired), meningitis, sepsis, urinary tract infections (UTIs), skin and soft tissue infections, bone and joint infections (such as septic arthritis), intra-abdominal infections including peritonitis (especially in peritoneal dialysis patients), malignant otitis externa, and various other severe or life-threatening conditions caused by susceptible bacteria[1][5][7]. It has high stability against many beta-lactamases produced by Gram-negative bacteria but can be hydrolyzed by extended-spectrum beta-lactamases (ESBLs) or carbapenemases.

Brand names

FortazAnsaidineKefadimTazicefCeptazCefzimZepizidimCeftidimeCeftumax

Other names

头孢他啶ceftazidime pentahydrate