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ceftazidime + avibactam + aztreonam
- Development stage
- Unknown
- Lead developer
- National Institute of Allergy and Infectious Diseases
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Ceftazidime + avibactam + aztreonam is a combination antibiotic therapy being evaluated by the National Institute of Allergy and Infectious Diseases (NIAID) for the treatment of infections caused by metallo-beta-lactamase (MBL)-producing Gram-negative bacteria. The combination leverages the unique properties of its components: aztreonam, a monobactam, is stable against hydrolysis by MBLs but susceptible to other beta-lactamases often co-produced by these pathogens. Avibactam, a non-beta-lactam beta-lactamase inhibitor, protects aztreonam from these co-produced enzymes (such as ESBLs and KPCs). Ceftazidime, a third-generation cephalosporin, is provided as part of the fixed-dose combination with avibactam (Avycaz). Together, this regimen aims to restore antibacterial activity against highly resistant Enterobacterales.
- Other names
- Ceftazidime-avibactam plus aztreonamCAZ-AVI + ATMCOMBINE study drug
02
Targets
PBP3 (Peptidoglycan D,D-transpeptidase FtsI)Neuraminidaseβ-lactamase
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