Drug intelligence / Profile preview

ceftibuten

Development stage
Approved
Lead developer
Venatorx Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

Ceftibuten is an orally administered, third-generation cephalosporin antibiotic used to treat a variety of bacterial infections. It is effective against pathogens such as *Haemophilus influenzae*, *Moraxella catarrhalis*, and certain strains of *Streptococcus pneumoniae* and *Streptococcus pyogenes*. Ceftibuten works by binding to penicillin-binding proteins (PBPs) in bacteria, inhibiting cell wall synthesis and leading to bacterial cell death. It is indicated for acute bacterial exacerbations of chronic bronchitis, acute otitis media, pharyngitis, tonsillitis, pneumonia, urinary tract infections, enteritis, and gastroenteritis[1][2][4][5][7]. The drug demonstrates high stability against many beta-lactamases but may be less effective against organisms with chromosomally-mediated resistance mechanisms[6].

Brand names
Cedax
Other names
ceftibutenceftibuten dihydrate
02

Targets

PBP1B (Penicillin-binding protein 1B)PBP2 (Penicillin-binding protein 2)PBP3 (Peptidoglycan D,D-transpeptidase FtsI)PBP1A (Penicillin-binding protein 1A)

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