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Ceftriaxone is a long-acting, semisynthetic **third-generation cephalosporin beta-lactam antibiotic** originally developed by Roche. It is administered parenterally as ceftriaxone sodium, typically by intravenous or intramuscular injection, for susceptible bacterial infections including lower respiratory tract infection, meningitis, septicemia, urinary tract infection, skin and soft-tissue infection, intra-abdominal infection, bone and joint infection, acute bacterial otitis media, gonorrhea, and pelvic inflammatory disease. It is bactericidal through inhibition of bacterial cell-wall synthesis and is marketed historically as Rocephin. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8351aa37-552d-471d-b293-c564dcb6ec29))
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