ceftriaxone + ciprofloxacin

A combination antibiotic therapy consisting of ceftriaxone (a third-generation cephalosporin) and ciprofloxacin (a second-generation fluoroquinolone). This combination provides broad-spectrum coverage against both gram-positive and gram-negative bacteria through complementary mechanisms of action. Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, while ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication. The combination has shown efficacy in treating various bacterial infections, including foodborne Vibrio vulnificus infections.