cefuroxime + clavulanate

Cefuroxime + clavulanate is an oral fixed-dose combination antibiotic consisting of cefuroxime axetil, a second-generation cephalosporin, and potassium clavulanate, a beta-lactamase inhibitor. Cefuroxime works by binding to penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis, leading to cell lysis. Clavulanate acts as a suicide inhibitor of beta-lactamase enzymes, preventing the enzymatic degradation of cefuroxime and restoring its activity against beta-lactamase-producing bacterial strains. This combination is widely used in countries like India for the treatment of various mild-to-moderate bacterial infections, including respiratory tract infections (bronchitis, pneumonia, sinusitis, tonsillitis), urinary tract infections, skin and soft tissue infections, and gonococcal urethritis. It is not approved by the US FDA.

Brand names

Augxetil-CVCefakind-CVCefasyn CVCefotune-CVCefukay CVCefurim CVCfuro-CVCorafax-CVCrintum-CVFastclavForcef-CVFurobis CVGilcin-CVHilcef CVOratil CVPlecacPulmotop-CVRetum-CVS CEF-CVXoxo-CVZefu-CVZocef-CV

Other names

cefuroxime and clavulanic acidcefuroxime and potassium clavulanatecefuroxime axetil + clavulanate potassiumcefuroxime axetil + potassium clavulanatecefuroxime axetil and potassium clavulanatecefuroxime axetil/potassium clavulanatecefuroxime/clavulanatecefuroxime/clavulanic acid