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celastrus orbiculatus extract
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Celastrus orbiculatus extract (COE) is a botanical extract derived from the Oriental bittersweet plant, a member of the Celastraceae family used in traditional Chinese medicine for its anti-inflammatory and anti-tumor properties. COE has demonstrated antineoplastic activity in preclinical models of hepatocellular carcinoma (HCC), specifically by inducing apoptosis through the inhibition of the mTOR signaling pathway. It modulates the expression of apoptosis-related proteins, including the down-regulation of Bcl-2 and Bcl-xL and the up-regulation of Bax and caspase-3. Research indicates its potential as a chemotherapeutic agent for HCC and other cancers.
- Other names
- Celastrus orbiculatus Thunb. extractCOEOriental bittersweet extract
02
Targets
BCL2L1 (B-cell lymphoma-extra large protein)BAX (Apoptosis regulator BAX)mTOR (Mammalian target of rapamycin kinase)CASP3 (Caspase-3)
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