Drug intelligence / Profile preview

celecoxib + buprenorphine

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Transdermal, Oral
01

Overview

A combination of celecoxib, a COX-2 inhibitor NSAID, and buprenorphine, an opioid analgesic. This combination leverages complementary mechanisms of action for pain management. Clinical studies have shown that the combination of buprenorphine transdermal patch with celecoxib capsules provides superior pain relief and functional improvement compared to either medication used alone, particularly in conditions like adhesive shoulder capsulitis.

02

Targets

MOR (Mu opioid receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NOP (Nociceptin/orphanin FQ peptide receptor)KOR (Kappa opioid receptor)

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