Drug intelligence / Profile preview

celecoxib + dexamethasone + dextromethorphan + gabapentin + ondansetron + paracetamol

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral, Intravenous, Intramuscular, Rectal
01

Overview

This is a combination of six different medications, each with distinct mechanisms of action: - **Celecoxib**: A selective cyclooxygenase-2 (COX-2) inhibitor and nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation with reduced risk of gastrointestinal bleeding compared to other NSAIDs. - **Dexamethasone**: A corticosteroid that works on the immune system to help relieve swelling, inflammation, and allergic reactions. - **Dextromethorphan**: A cough suppressant that affects signals in the brain that trigger the cough reflex. - **Gabapentin**: An anticonvulsant and nerve pain medication that works by affecting chemicals and nerves in the body that are involved in seizures and pain. - **Ondansetron**: A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting. - **Paracetamol** (Acetaminophen): A non-opioid analgesic and antipyretic that reduces pain and fever by inhibiting prostaglandin production. This multi-drug combination may be used for complex pain management scenarios requiring anti-inflammatory, corticosteroid, neuropathic pain, and anti-emetic effects simultaneously.

02

Targets

SERT (Sodium-dependent serotonin transporter)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)SIGMAR1 (Sigma non-opioid intracellular receptor 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)GR (Glucocorticoid receptor)CACNA2D2 (α2δ-2)PGHS-1 (Prostaglandin G/H Synthase 1)GluR (Glutamate receptors)

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