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celecoxib + pregabalin + vitamin b
- Development stage
- Unknown
- Lead developer
- Laboratorios Silanes
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
A fixed-dose combination of celecoxib, pregabalin, and vitamin B is under investigation for the treatment of chronic low back pain. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that reduces inflammation and pain by inhibiting prostaglandin synthesis. Pregabalin acts as an anticonvulsant and analgesic by binding to the alpha2-delta subunit of voltage-dependent calcium channels in the central nervous system, thereby reducing neurotransmitter release involved in pain signaling. Vitamin B (typically referring to a combination of B1, B6, and/or B12) is included for its potential neuroprotective effects and support in nerve function. The combination aims to address both nociceptive and neuropathic components of chronic low back pain with improved efficacy over monotherapy or dual therapy regimens[1][2][3][4][5].
- Other names
- Celecoxib/Pregabalin/Vitamin B
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)
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