celecoxib + vitamin b

Celecoxib + vitamin B is a fixed-dose combination of the nonsteroidal anti-inflammatory drug (NSAID) celecoxib and one or more B vitamins, typically used for the management of chronic low back pain. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that reduces inflammation and pain by inhibiting prostaglandin synthesis. The addition of B vitamins, often including thiamine (B1), pyridoxine (B6), and cyanocobalamin (B12), is intended to support nerve health and potentially enhance analgesic effects. Clinical studies have shown that this combination can provide greater relief from chronic pain syndromes compared to celecoxib alone, with improved restoration of motor function in patients with nonspecific lumbar pain[2][3]. The combination has been evaluated in phase III clinical trials for chronic low back pain.