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celecoxib topical
- Development stage
- Unknown
- Lead developer
- Promius Pharma, LLC
- Modality
- Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical
01
Overview
Celecoxib topical (DFD-07) is a 1.25% cream formulation of celecoxib, a selective cyclo-oxygenase 2 (COX-2) inhibitor. It is being developed for the treatment of actinic keratosis, a precancerous skin condition characterized by rough, scaly patches on sun-exposed areas such as the face and scalp. The drug acts by inhibiting COX-2, thereby reducing inflammation and potentially exerting keratolytic effects that help clear actinic keratosis lesions. DFD-07 is applied topically to affected skin areas and has been evaluated in randomized controlled clinical trials for safety and efficacy in this indication[5][7].
- Other names
- celecoxib topicalDFD-07 creamDFD07 creamDFD 07 cream
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)
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