celery seed extract + boswellia serrata extract + phellodendron bark extract

This combination is a botanical formulation used primarily as a dietary supplement for the management of joint pain and inflammatory conditions such as osteoarthritis. The formulation leverages the synergistic effects of three distinct plant extracts. **Boswellia serrata extract**, particularly when standardized to 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), is a potent inhibitor of **5-lipoxygenase (5-LOX)**, thereby reducing the production of pro-inflammatory leukotrienes. **Phellodendron bark extract** (Phellodendron amurense), often provided as the branded ingredient **Nexrutine**, contains alkaloids like berberine that inhibit **cyclooxygenase-2 (COX-2)** and the **NF-kappaB** signaling pathway. **Celery seed extract** (Apium graveolens) contributes phthalides (such as 3-n-butylphthalide) which have demonstrated anti-inflammatory properties and the ability to inhibit **xanthine oxidase**, potentially aiding in the management of uric acid levels. This combination is typically administered orally to support joint mobility and reduce systemic inflammation.

Other names

Apium graveolens + Boswellia serrata + Phellodendron amurensecelery seed + boswellia + phellodendron