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Cellgram-DC-PC
- Development stage
- Preclinical
- Lead developer
- Pharmicell
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies
- Administration
- Subcutaneous Injection
01
Overview
Cellgram-DC-PC is an autologous dendritic cell-based cancer vaccine developed by Pharmicell for the treatment of metastatic castration-resistant prostate cancer (mCRPC) and has also been investigated in ovarian and pancreatic cancers. The therapy involves isolating a patient's own dendritic cells, which are then processed and reintroduced to stimulate the immune system—specifically T lymphocytes—against cancer cells. Its mechanism of action centers on immunostimulation and T lymphocyte activation to enhance anti-tumor immunity. Clinical development has included phase 1 trials in prostate cancer; however, some studies have been terminated due to recruitment challenges[1][2][5].
- Brand names
- Cellgram-DC-PCCellgram DC
- Other names
- autologous dendritic cell anticancer immune cell therapyautologous dendritic cells vaccine - Pharmicell
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