Drug intelligence / Profile preview

centella asiatica

Development stage
Phase 4
Lead developer
Indena
Administration
Oral, Topical
01

Overview

Centella asiatica is a medicinal herb widely used in traditional Chinese and Ayurvedic medicine, as well as in modern dietary supplements and topical products. Its primary active constituents are triterpenoid saponins, including asiaticoside, madecassoside, asiatic acid, and madecassic acid. These compounds are believed to be responsible for its therapeutic effects such as wound healing (by increasing collagen synthesis), anti-inflammatory activity, antioxidant properties, anxiolytic effects (possibly via increased cerebral GABA levels), and potential benefits for skin conditions like psoriasis and scleroderma. Centella asiatica is not an approved pharmaceutical drug but is commonly found in over-the-counter products for skin care and health supplements[1][2][3][4][5][8].

Brand names
MadecassolEVES CENTELLA 20 V1 VOLUME AMPOULE
Other names
gotu kola
02

Targets

GABRR (GABA-A receptor subunit rho)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)

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