Drug intelligence / Profile preview

centella asiatica leaf extract

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Centella asiatica leaf extract is a botanical extract derived from the leaves of the Centella asiatica plant, commonly known as Gotu Kola, Tiger Grass, or Cica. It is widely used in cosmetic, dermatological, and phytotherapeutic applications due to its rich content of biologically active pentacyclic triterpenoid saponins, collectively known as centellosides (including asiaticoside, madecassoside, asiatic acid, and madecassic acid). These active compounds stimulate glycosaminoglycan synthesis, promote collagen expression, and exhibit potent anti-inflammatory, antioxidant, and wound-healing properties. While primarily utilized topically in skincare formulations for wound healing, anti-aging, and soothing inflammation, it has also been investigated for potential antibacterial activity and cognitive enhancement.

Other names
Centella asiatica extractCica extractGotu Kola extractGotu Kola leaf extractTiger Grass extract
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)Misfolded SOD1GPX4 (Glutathione peroxidase 4)NF-κBTGF-beta/Smad (Transforming growth factor beta/Smad signaling axis)

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