Center-Al grass pollen extract

Center-Al grass pollen extract is an alum-precipitated allergenic biologic used for allergen-specific immunotherapy. In the clinical trial context led by Amber Patterson, this extract is being evaluated for intralymphatic immunotherapy (ILIT) in adolescents and young adults with allergic rhinitis and rhinoconjunctivitis. ILIT involves the direct injection of the allergen into a lymph node to induce rapid immune tolerance, potentially offering a more efficient alternative to traditional subcutaneous immunotherapy (SCIT) by requiring fewer doses and lower allergen concentrations. The extract works by modulating the immune system's response to grass pollen, promoting the expansion of regulatory T cells and shifting the antibody profile from IgE-mediated allergic inflammation toward a protective IgG4-mediated response.

Brand names

Center-Al

Other names

Grass pollen extractAlum-precipitated grass pollen extractAllergen-specific intralymphatic immunotherapy grass pollen extract