Drug intelligence / Profile preview

centipeda minima

Development stage
Phase 1
Lead developer
Zhejiang Hospital of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Topical, Intranasal
01

Overview

*Centipeda minima* is a botanical drug derived from the whole plant of *Centipeda minima* (L.) A. Braun & Asch., a species widely recognized in Traditional Chinese Medicine as E Bu Shi Cao. It is primarily investigated for its therapeutic potential in respiratory and inflammatory conditions, most notably allergic rhinitis. The herb's pharmacological profile is characterized by its rich content of sesquiterpene lactones, such as brevilin A and arnicolide C, which exert potent anti-inflammatory and anti-allergic effects. These compounds are known to inhibit the release of inflammatory mediators (e.g., histamine, leukotrienes) and suppress the activation of the NF-kappaB signaling pathway. In clinical trials, such as those conducted by The First Affiliated Hospital of Zhejiang Chinese Medicine University, *Centipeda minima* is often administered as a topical powder or as part of a multi-herb formulation to alleviate nasal congestion and improve quality of life in patients with allergic rhinitis.

Brand names
ANACELL
Other names
E Bu Shi CaoSmall Centipeda HerbCentipeda minima (L.) A. Braun & Asch.鹅不食草
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)MAPK3 (Mitogen-activated protein kinase 1)NOS2 (Nitric Oxide Synthase 2)NOX2/NOX4 (NADPH oxidase 2 and NADPH oxidase 4)

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