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Central China Normal Univ. HPK1 compound 5i
- Development stage
- Unknown
- Lead developer
- Central China Normal University
01
Overview
Central China Normal Univ. HPK1 compound 5i: sourced facts only. name: "The identified candidate compound 5i exhibited HPK1 inhibition with an IC50 value of 0.8 nM and 101.3-fold selectivity against GLK." [PMID:36542759]; target: "The identified candidate compound 5i exhibited HPK1 inhibition with an IC50 value of 0.8 nM and 101.3-fold selectivity against GLK." [PMID:36542759]; developer: "Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. of China." [PMID:36542759]; stage: "More importantly, compound 5i demonstrated a clear synergistic effect with anti-PD-1 in both MC38 (MSI) and CT26 (MSS) syngeneic tumor mouse models." [PMID:36542759]
02
Targets
MAP4K1 (Hematopoietic progenitor kinase 1)
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