Central South Univ. AMPKα1 compound 22f

Central South Univ. AMPKα1 compound 22f: sourced facts only. name: "Among these, 22f demonstrated superior in vitro AMPKα1 activity (EC50 = 35.1 ± 1.20 nM) and selectivity (176-fold over AMPKα2), coupled with a significant protective effect in NRK-52E cells subjected to hypoxia-reoxygenation injury." [PMID:41494467]; target: "Among these, 22f demonstrated superior in vitro AMPKα1 activity (EC50 = 35.1 ± 1.20 nM) and selectivity (176-fold over AMPKα2), coupled with a significant protective effect in NRK-52E cells subjected to hypoxia-reoxygenation injury." [PMID:41494467]; developer: "Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Small Molecules for Diagnosis and Treatment of Chronic Disease, Changsha, Hunan, China; Hunan Key Laboratory of Organ Fibrosis, Changsha, Hunan, China." [PMID:41494467]; stage: "Furthermore, in an RIRI mice model, 22f selectively activated renal AMPKα1, significantly attenuating serum creatinine and blood urea nitrogen levels." [PMID:41494467]