Drug intelligence / Profile preview

centratherum anthelminticum fixed oil

Development stage
Unknown
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration
Oral, Topical
01

Overview

Centratherum anthelminticum fixed oil is the non-volatile (fixed) lipid fraction extracted from the seeds of Centratherum anthelminticum, a plant widely used in traditional Ayurvedic medicine. The seeds contain approximately 18% fixed oil, which is rich in fatty acids such as linoleic acid, palmitic acid, stearic acid, oleic acid, and vernolic acid[2][5]. This fixed oil exhibits multiple pharmacological properties including strong anthelmintic (anti-parasitic), antibacterial, anti-inflammatory, antioxidant, antihyperglycemic (blood sugar-lowering), and wound-healing activities[2][5]. Mechanistically, its effects are attributed to bioactive compounds like flavonoids and sterols that modulate inflammatory pathways (e.g., downregulation of NF-κB), oxidative stress responses (e.g., upregulation of catalase and other antioxidants), and metabolic processes relevant to diabetes and hyperlipidemia[1][6]. It is traditionally used for treating intestinal worms (roundworms/tapeworms/threadworms), skin diseases such as eczema or vitiligo due to its ability to promote melanin synthesis and wound healing; it also finds use in managing diabetes mellitus by improving glycemic control[2][4][5].

Brand names
centratherum anthelminticum fixed oil
Other names
kalijiri fixed oilkali jeeri fixed oilbitter cumin seed oilaryana jeerak fixed oil
02

Targets

GPX1 (Glutathione peroxidase 1)TGR (Thioredoxin-glutathione reductase)GST (Glutathione S-transferase alpha 3)

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