CEP-9722

CEP-9722 is a small-molecule prodrug of CEP-8983, which is a selective and orally active inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2. By inhibiting PARP1 and PARP2, CEP-9722 interferes with DNA repair mechanisms in tumor cells, specifically base excision repair (BER), leading to the accumulation of DNA strand breaks, genomic instability, and apoptosis. This mechanism may enhance the cytotoxicity of DNA-damaging agents and help overcome tumor cell resistance to chemotherapy or radiotherapy. The drug has been investigated in phase 1 clinical trials for advanced solid tumors, both as monotherapy and in combination with agents such as temozolomide or gemcitabine/cisplatin[1][2][3][4][5][7].

Other names

916574-83-9UNII-B68083E4YGUNII-B-68083E4YGUNII-B 68083E4YG