cephaloglycin

Cephaloglycin is a semisynthetic first-generation cephalosporin antibiotic that was introduced in 1965 as the first oral cephalosporin but is no longer in common use[3][5][7]. It is an orally absorbed derivative of cephalosporin C and exhibits antibacterial activity by binding to and inactivating penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall[1][5][7]. PBPs are enzymes involved in assembling and reshaping the bacterial cell wall; their inhibition interferes with peptidoglycan cross-linking, weakening the cell wall and causing bacterial lysis[5][7]. Cephaloglycin was primarily indicated for severe infections caused by susceptible bacteria[2].

Brand names

Kafocin

Other names

cephaloglycin3-acetoxymethyl-7beta-(2R)-2-amino-2-phenylacetamido)-3,4-didehydrocepham-4-carboxylic acid7-(D-alpha-Aminophenylacetamido)-cephalosporanic acid dihydrate5-Thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic acid, 3-(acetyloxy)methyl)-7-(aminophenylacetyl)amino)-8‑oxo-, (6R-(6alpha,7beta(R*))), dihydrate