Drug intelligence / Profile preview

ceratonia siliqua aqueous extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

*Ceratonia siliqua aqueous extract* refers to the water-based extract obtained from the leaves or pods of the Ceratonia siliqua (carob) plant. It is traditionally used in Mediterranean folk medicine for its diverse therapeutic activities, including **antioxidant**, **antidiabetic**, **antidiarrheal**, **memory-enhancing**, and **antiatherosclerotic** effects[1]. The extract contains high levels of bioactive phenolic compounds and flavonoids, with major constituents such as gallic acid, epicatechin, chlorogenic acid, caffeic acid, quercetin-3-glucoside, luteolin-7-glucoside, and apigenin-7-glucoside[1]. Mechanistically, it acts as a **free radical scavenger** and an **acetylcholinesterase inhibitor**, with evidence of cognitive enhancement and anxiolytic effects in animal models[1]. Additional studies show anti-inflammatory, hepatoprotective, anticancer, antibacterial, anti-cobalt-toxicity, antidepressant, anti-obesity, and immunomodulatory activities, depending on the source and plant material used for extraction[2][3].

Other names
carob leaf aqueous extractcarob pod aqueous extractCsAECeratonia siliqua leaf extractCeratonia siliqua pod extract
02

Targets

Sucrase-IsomaltaseABCB1 (P-glycoprotein)CYP3A4 (Cytochrome P450 3A4)ButyrylcholinesteraseCYP2C9 (Cytochrome P450 family 2 subfamily C member 9)CYP2C19 (Cytochrome P450 2C19)Acetylcholinesterase

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