Drug intelligence / Profile preview

Ceratonia siliqua extract

Development stage
Unknown
Lead developer
Pharmactive Biotech Products
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Ceratonia siliqua extract, commonly known as carob extract, is a botanical extract derived from the pods, pulp, or seeds of the *Ceratonia siliqua* (carob) tree. It is rich in bioactive compounds, including dietary fibers (such as galactomannans), inositols (such as D-pinitol), and polyphenols (such as gallic acid, flavonoids, and tannins). The extract exhibits potent antioxidant, anti-inflammatory, and anti-apoptotic properties. In preclinical models, it has been shown to protect the ovarian reserve against chemotherapy-induced damage (such as cyclophosphamide-induced toxicity) by modulating Bax/Bcl-2-mediated apoptosis, and to alleviate doxorubicin-induced nephrotoxicity. Additionally, standardized formulations like Csat are investigated for weight management, metabolic health, and appetite regulation due to their ability to stimulate the secretion of satiety hormones like GLP-1 and cholecystokinin (CCK), as well as improving lipid profiles and glycemic control.

Brand names
Csat
Other names
carob extractcarob pod extractcarob pulp extractcarob seed extractCeratonia siliqua L. extractCeratonia siliqua pods extractCeratonia siliqua seed extract
02

Targets

AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase

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