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Cerebraca wafer
- Development stage
- Unknown
- Lead developer
- Everfront Biotech
- Modality
- Small Molecules
- Administration
- Implant, Intracranial
01
Overview
Cerebraca wafer is a biodegradable polymer wafer containing 25% (Z)-n-butylidenephthalide (BP) and 75% poly[carboxyphenoxy-propane/sebacic acid] (CPPSA) copolymer designed for direct implantation into the surgical cavity after brain tumor resection. It slowly releases BP over 14-21 days to eliminate residual tumor cells. The therapeutic mechanism involves BP's cytotoxic effect against tumor stem cells, synergistic effect with temozolomide, and inhibition of PD-L1 protein levels to activate T-cell cytotoxicity.
- Brand names
- Cerebraca wafer
- Other names
- Cerebraca
02
Targets
SOX2 (SRY-box transcription factor 2)TERT (Telomerase)CD274 (Programmed cell death protein 1 ligand 1)NR4A1 (Nuclear receptor subfamily 4 group A member 1)AGT (O6-methylguanine-DNA methyltransferase)AXL (AXL receptor tyrosine kinase)EZH2 (Histone-lysine N-methyltransferase EZH2)
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